Human embryonic stem cell-derived mesenchymal stromal cells
نویسندگان
چکیده
منابع مشابه
Mesenchymal Stem/Stromal-Like Cells from Diploid and Triploid Human Embryonic Stem Cells Display Different Gene Expression Profiles
Background: Human ESCs-MSCs open a new insight into future cell therapy applications, due to their unique characteristics, including immunomodulatory features, proliferation, and differentiation. Methods: Herein, hESCs-MSCs were characterized by IF technique with CD105 and FIBRONECTIN as markers and FIBRONECTIN, VIMENTIN, CD10, CD105, and CD14 genes using RT-PCR technique. FACS was performed fo...
متن کاملHuman Embryonic Stem Cells Derived Mesenchymal Stem/Stromal Cells and their Use in Regenerative Medicine
Recently, studies focused on mesenchymal stem/stromal cells (MSCs) as progenitor cells due to their capacity to regenerate mesodermal tissues such as cartilage, adipose and bone. However, there are practical and ethical challenges regarding the isolation of these cells from different sources (mainly bone marrow). The ability to produce MSCs from human embryonic stem cells (hESCs) could be valua...
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Discovering a cell type with the highest efficiency and the least side-effects is one of the priorities of scientists active in this field. Of all the cells, mesenchymal stem cells have been and still are of interest to the researchers for use in pre-clinical and clinical studies due to being easily accessible, pluripotency, secretion of numerous growth factors, low risk of immunological reject...
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The aim of this study was to isolate mouse embryonic stem cells from late blastocyst stage embryos and to use them as a model system for the study of hematopoietic induction outside the embryo by coculturing of embryonic stem cells with bone marrow stromal cells. Blastocyst stage embryos from pregnant NMRI mice were obtained and cultured for 1-2 days in DMEM medium. The inner cell masses formed...
متن کاملHuman embryonic stem cell-derived mesenchymal stromal cells ameliorate collagen-induced arthritis by inducing host-derived indoleamine 2,3 dioxygenase.
BACKGROUND The immunosuppressive and anti-inflammatory properties of mesenchymal stromal cells (MSC) have prompted their therapeutic application in several autoimmune diseases, including rheumatoid arthritis. Adult MSC are finite and their clinical use is restricted by the need for long-term expansion protocols that can lead to genomic instability. Inhibition of Smad2/3 signaling in human pluri...
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ژورنال
عنوان ژورنال: Transfusion
سال: 2011
ISSN: 0041-1132
DOI: 10.1111/j.1537-2995.2011.03376.x